Trends and targets in antiviral phototherapy

A Wiehe, JM O'Brien, MO Senge - Photochemical & Photobiological …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a well-established treatment option in the treatment of
certain cancerous and pre-cancerous lesions. Though best-known for its application in …

Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem/stromal cells: present and future

G Astori, E Amati, F Bambi, M Bernardi… - Stem cell research & …, 2016 - Springer
The use of fetal bovine serum (FBS) as a cell culture supplement is discouraged by
regulatory authorities to limit the risk of zoonoses and xenogeneic immune reactions in the …

Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & …

K Bieback, B Fernandez-Munoz, S Pati, R Schäfer - Cytotherapy, 2019 - Elsevier
Fetal bovine serum (FBS) is used as a growth supplement in a wide range of cell culture
applications for cell-based research and therapy. However, as a xenogenic product, FBS …

[HTML][HTML] The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates

J Kaiser-Guignard, G Canellini, N Lion, M Abonnenc… - Blood reviews, 2014 - Elsevier
Since 1990, several techniques have been developed to photochemically inactivate
pathogens in platelet concentrates, potentially leading to safer transfusion therapy. The …

Cold-stored platelets: A product with function optimized for hemorrhage control

KM Reddoch-Cardenas, JA Bynum… - … and Apheresis Science, 2019 - Elsevier
Early administration of blood products following severe trauma is pivotal for establishing
hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide …

The non-hemostatic aspects of transfused platelets

C Sut, S Tariket, C Aubron, C Aloui… - Frontiers in …, 2018 - frontiersin.org
Platelets transfusion is a safe process, but during or after the process, the recipient may
experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this …

[HTML][HTML] The European hematology association roadmap for European hematology research: a consensus document

A Engert, C Balduini, A Brand, B Coiffier… - …, 2016 - ncbi.nlm.nih.gov
Abstract The European Hematology Association (EHA) Roadmap for European Hematology
Research highlights major achievements in diagnosis and treatment of blood disorders and …

[HTML][HTML] Antimicrobial 405 nm violet-blue light treatment of ex vivo human platelets leads to mitochondrial metabolic reprogramming and potential alteration of …

S Jana, MR Heaven, N Dahiya, C Stewart… - … of Photochemistry and …, 2023 - Elsevier
Continued efforts to reduce the risk of transfusion-transmitted infections (TTIs) through blood
and blood components led to the development of ultraviolet (UV) light irradiation …

Omics markers of platelet transfusion in trauma patients

IS LaCroix, M Cohen, EE Moore… - …, 2023 - Wiley Online Library
Background Even in the era of the COVID‐19 pandemic, trauma remains the global leading
cause of mortality under the age of 49. Trauma‐induced coagulopathy is a leading driver of …

Impact of different pathogen reduction technologies on the biochemistry, function, and clinical effectiveness of platelet concentrates: An updated view during a …

G Escolar, M Diaz‐Ricart, J McCullough - Transfusion, 2022 - Wiley Online Library
Standard platelet concentrates (PCs) stored at 22° C have a limited shelf life of 5 days.
Because of the storage temperature, bacterial contamination of PCs can result in life …