The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …

Noise caused by stochastic fluctuations in genetic circuits (transcription and translation) is
now appreciated as a central aspect of cell function and phenotypic behavior. Noise has …

The Nef protein of the human immunodeficiency virus is as important for disease
progression as it is perplexing in its plethora of target molecules and functions. In this article …

Engineered T cells hold great promise to become part of an effective HIV cure strategy, but it
is currently unclear how best to redirect T cells to target HIV. To gain insight, we generated …

Human immunodeficiency virus, type 1, negative factor (Nef) initiates down-regulation of cell-
surface major histocompatibility complex-I (MHC-I) by assembling an Src family kinase …

Advances in the last several years have enhanced mechanistic understanding of Nef-
induced CD4 and MHCI downregulation and have suggested a new paradigm for analyzing …

The HIV accessory protein Nef modulates key immune evasion and pathogenic functions,
and its encoding gene region exhibits high sequence diversity. Given the recent …

Background The highly genetically diverse HIV-1 group M subtypes may differ in their
biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a …

Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …