Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Background: Previously we identified a DNA damage response–deficient (DDRD) molecular
subtype within breast cancer. A 44-gene assay identifying this subtype was validated as …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all
human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing …

The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …

Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …

Background Autophagy, a process for degrading intracellular substances to maintain basal
metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 …

As one of the two highly conserved cellular degradation systems, autophagy plays a critical
role in regulation of protein, lipid, and organelle quality control and cellular homeostasis …

Autophagy is an essential cellular process that is deeply integrated with innate immune
signaling; however, studies that examine the impact of autophagic modulation in the context …