The fourth edition of the World Health Organization (WHO) classification of urogenital
tumours (WHO “blue book”), published in 2016, contains significant revisions. These …

Purpose Pathological parameters assessed on biopsies and resection specimens have a
pivotal role in the diagnosis, prognosis and management of patients with renal cell …

PURPOSE To provide recommendations for the management of patients with metastatic
clear cell renal cell carcinoma (ccRCC). METHODS An Expert Panel conducted a systematic …

Abstract The International Society of Urological Pathology 2012 Consensus Conference
made recommendations regarding classification, prognostic factors, staging, and …

Clinical specimens are each inherently unique, limited and nonrenewable. Small samples
such as tissue biopsies are often completely consumed after a limited number of analyses …

Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone
to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma …

The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …

Background Over 90% of cancer-related deaths in clear cell renal cell carcinoma (RCC) are
caused by tumor relapse and metastasis. Thus, there is an urgent need for new molecular …

Primary renal neoplasms comprise multiple distinct entities, some of which are well
understood and others that are not. It is not uncommon for some of these entities to have …

Carcinoma of unknown primary origin (CUP) is one of the 10 most prevalent malignancies.
CUP patients in whom a site of origin can be ascribed have better outcomes than those in …