Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

Background: Some patients who have a total hip replacement with a second-generation
metal-on-metal articulation have persistent or early recurrence of preoperative symptoms …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Multiple sclerosis is a chronic inflammatory disease of the nervous system in which a T-cell-
mediated inflammatory process is associated with destruction of myelin sheaths. Although …

Nitric oxide (NO) is a free radical found at higher than normal concentrations within
inflammatory multiple sclerosis (MS) lesions. These high concentrations are due to the …

The matrix metalloproteinases and related A disintegrin and metalloproteinase enzymes are
implicated in various diseases of the nervous system. However, metalloproteinases are …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Multiple sclerosis is characterized by the infiltration of leukocytes into the CNS. As matrix
metalloproteinases (MMPs) facilitate the passage of leukocytes across matrix barriers, we …

Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with
surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the …