Dual-specificity MAP kinase (MAPK) phosphatases (MKPs or DUSPs) are well-established
negative regulators of MAPK signalling in mammalian cells and tissues. By virtue of their …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

Despite available targeted treatments for the disease, drug-resistant chronic lymphocytic
leukemia (CLL) poses a clinical challenge. The objective of this study is to examine whether …

The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …

It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …

Phosphatases and kinases maintain an equilibrium of dephosphorylated and
phosphorylated proteins, respectively, that are required for critical cellular functions …

Synthetic lethality results when mutant KRAS and EGFR proteins are co-expressed in
human lung adenocarcinoma (LUAD) cells, revealing the biological basis for mutual …

Malignant transformation of cells typically involves several genetic lesions, whose combined
activity gives rise to cancer. Here we analyse 1,148 patient-derived B-cell leukaemia (B …