The impact of the gut microbiome on extra-intestinal autoimmune diseases

E Miyauchi, C Shimokawa, A Steimle… - Nature Reviews …, 2023 - nature.com
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

[HTML][HTML] Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

The gut microbiota is associated with immune cell dynamics in humans

J Schluter, JU Peled, BP Taylor, KA Markey, M Smith… - Nature, 2020 - nature.com
The gut microbiota influences development,–and homeostasis,,–of the mammalian immune
system, and is associated with human inflammatory and immune diseases, as well as …

Ruminococcus gnavus: friend or foe for human health

EH Crost, E Coletto, A Bell… - FEMS microbiology …, 2023 - academic.oup.com
Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy
individuals, and for several decades, its study has been limited to specific enzymes or …

Host–microbiota interactions in immune-mediated diseases

WE Ruff, TM Greiling, MA Kriegel - Nature Reviews Microbiology, 2020 - nature.com
Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

[PDF][PDF] The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

H Zhu, C Cao, Z Wu, H Zhang, Z Sun, M Wang, H Xu… - Cell metabolism, 2021 - cell.com
The relationship between gut microbial dysbiosis and acute or chronic kidney disease
(CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus …

[HTML][HTML] Causal effects of gut microbiome on systemic lupus erythematosus: a two-sample Mendelian randomization study

K Xiang, P Wang, Z Xu, YQ Hu, YS He, Y Chen… - Frontiers in …, 2021 - frontiersin.org
The observational association between gut microbiome and systemic lupus erythematosus
(SLE) has been well documented. However, whether the association is causal remains …

New insights into the role of antinuclear antibodies in systemic lupus erythematosus

DS Pisetsky, PE Lipsky - Nature Reviews Rheumatology, 2020 - nature.com
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial

C Huang, P Yi, M Zhu, W Zhou, B Zhang, X Yi… - Journal of …, 2022 - Elsevier
Gut microbiota dysbiosis is involved in the development of systemic lupus erythematosus
(SLE). The safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of …