Drug repurposing: A strategy for discovering inhibitors against emerging viral infections

IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …

Advances in computational methods to discover new NS2B-NS3 inhibitors useful against dengue and Zika viruses

IJ dos Santos Nascimento… - Current Topics in …, 2022 - ingentaconnect.com
The Flaviviridae virus family consists of the genera Hepacivirus, Pestivirus, and Flavivirus,
with approximately 70 viral types that use arthropods as vectors. Among these diseases …

High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment

B Naik, N Gupta, R Ojha, S Singh, VK Prajapati… - International Journal of …, 2020 - Elsevier
The present-day world is severely suffering from the recently emerged SARS-CoV-2. The
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …

Broad-spectrum host-based antivirals targeting the interferon and lipogenesis pathways as potential treatment options for the pandemic coronavirus disease 2019 …

S Yuan, CCY Chan, KKH Chik, JOL Tsang, R Liang… - Viruses, 2020 - mdpi.com
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion …

Identification of Novel SARS‐CoV‐2 Inhibitors: A Structure‐Based Virtual Screening Approach

A El Aissouq, O Chedadi, M Bouachrine… - Journal of …, 2021 - Wiley Online Library
The recent outbreak of the coronavirus disease 2019 (COVID‐19) caused by SARS‐CoV‐2
(severe acute respiratory syndrome coronavirus 2) in the last few months raised global …

Toward an understanding of pan-assay interference compounds and promiscuity: a structural perspective on binding modes

SN Bolz, MF Adasme, M Schroeder - Journal of Chemical …, 2021 - ACS Publications
Pan-assay interference compounds (PAINS) are promiscuous compound classes that
produce false positive hits in high-throughput screenings. Yet, the mechanisms of PAINS …

NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review

DAF Nunes, FRS Santos… - Journal of Medical …, 2022 - Wiley Online Library
Zika virus (ZIKV) infections are associated with severe neurological complications and are a
global public health concern. There are no approved vaccines or antiviral drugs to inhibit …

Rational designing of peptide-ligand conjugates-based immunotherapy for the treatment of complicated malaria

P Godara, B Naik, R Meghwal, R Ojha, V Srivastava… - Life Sciences, 2022 - Elsevier
Aims Malaria deaths occur primarily due to complicated malaria associated with the
sequestration of Plasmodium falciparum-infected erythrocyte (Pf IE) in the capillary …

[HTML][HTML] Pharmacophore-Assisted Covalent Docking Identifies a Potential Covalent Inhibitor for Drug-Resistant Genotype 3 Variants of Hepatitis C Viral NS3/4A Serine …

K Iman, MU Mirza, F Sadia, M Froeyen, JF Trant… - Viruses, 2024 - mdpi.com
The emergence of drug-resistance-inducing mutations in Hepatitis C virus (HCV) coupled
with genotypic heterogeneity has made targeting NS3/4A serine protease difficult. In this …

Borane–Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2

Y Zhang, H Zhang, K Gao - Organic Letters, 2021 - ACS Publications
We report herein that a borane–trimethylamine complex worked as an efficient reducing
agent for the selective methylation and formylation of amines with 1 atm CO2 under metal …