CRISPR-Cas in Streptococcus pyogenes
A Le Rhun, A Escalera-Maurer, M Bratovič… - RNA biology, 2019 - Taylor & Francis
The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led
to a revolution in genome editing and engineering technologies. Despite the fact that most …
to a revolution in genome editing and engineering technologies. Despite the fact that most …
Endogenous type I CRISPR-Cas: from foreign DNA defense to prokaryotic engineering
Y Zheng, J Li, B Wang, J Han, Y Hao… - … in bioengineering and …, 2020 - frontiersin.org
Establishment of production platforms through prokaryotic engineering in microbial
organisms would be one of the most efficient means for chemicals, protein, and biofuels …
organisms would be one of the most efficient means for chemicals, protein, and biofuels …
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
I Fonfara, H Richter, M Bratovič, A Le Rhun… - Nature, 2016 - nature.com
CRISPR–Cas systems that provide defence against mobile genetic elements in bacteria and
archaea have evolved a variety of mechanisms to target and cleave RNA or DNA. The well …
archaea have evolved a variety of mechanisms to target and cleave RNA or DNA. The well …
Cutting it close: CRISPR-associated endoribonuclease structure and function
ML Hochstrasser, JA Doudna - Trends in biochemical sciences, 2015 - cell.com
Many bacteria and archaea possess an adaptive immune system consisting of repetitive
genetic elements known as clustered regularly interspaced short palindromic repeats …
genetic elements known as clustered regularly interspaced short palindromic repeats …
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
A Plagens, H Richter, E Charpentier… - FEMS microbiology …, 2015 - academic.oup.com
The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-
associated) adaptive immune systems use small guide RNAs, the CRISPR RNAs (crRNAs) …
associated) adaptive immune systems use small guide RNAs, the CRISPR RNAs (crRNAs) …
RNA-independent DNA cleavage activities of Cas9 and Cas12a
R Sundaresan, HP Parameshwaran, SD Yogesha… - Cell reports, 2017 - cell.com
CRISPR-Cas systems provide bacteria and archaea with sequence-specific protection
against invading mobile genetic elements. In the presence of divalent metal ions, Cas9 and …
against invading mobile genetic elements. In the presence of divalent metal ions, Cas9 and …
DNA targeting by a minimal CRISPR RNA-guided cascade
Bacteria employ surveillance complexes guided by CRISPR (clustered, regularly
interspaced, short palindromic repeats) RNAs (crRNAs) to target foreign nucleic acids for …
interspaced, short palindromic repeats) RNAs (crRNAs) to target foreign nucleic acids for …
The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR–Cas subtype III-Bv system
Specialized RNA endonucleases for the maturation of clustered regularly interspaced short
palindromic repeat (CRISPR)-derived RNAs (crRNAs) are critical in CRISPR–CRISPR …
palindromic repeat (CRISPR)-derived RNAs (crRNAs) are critical in CRISPR–CRISPR …
Approaches to study CRISPR RNA biogenesis and the key players involved
J Behler, WR Hess - Methods, 2020 - Elsevier
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) proteins provide an inheritable and adaptive immune system against …
associated (Cas) proteins provide an inheritable and adaptive immune system against …
The role of Cas8 in type I CRISPR interference
SDB Cass, KA Haas, B Stoll, OS Alkhnbashi… - Bioscience …, 2015 - portlandpress.com
CRISPR (clustered regularly interspaced short palindromic repeat) systems provide bacteria
and archaea with adaptive immunity to repel invasive genetic elements. Type I systems use …
and archaea with adaptive immunity to repel invasive genetic elements. Type I systems use …