Microtubule-mediated transport of macromolecules and organelles (also known as" cargo")
is essential for cells to function. Deficiencies in cytoplasmic transport are frequently …

Nonviral vectors continue to be attractive alternatives to viruses due to their low toxicity and
immunogenicity, lack of pathogenicity, and ease of pharmacologic production. However …

It is now clear that transport on microtubules by dynein and kinesin family motors has an
important if not critical role in the replication and spread of many different viruses …

The actin and microtubule cytoskeleton play important roles in the life cycle of every virus.
During attachment, internalization, endocytosis, nuclear targeting, transcription, replication …

Many viruses depend on host microtubule motors to reach their destined intracellular
location. Viral particles of neurotropic alphaherpesviruses such as herpes simplex virus 1 …

Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the
cell, are involved in many essential cellular processes. The major form of this enzyme is a …

Herpes simplex virus, varicella zoster virus, and pseudorabies virus are neurotropic
pathogens of the Alphaherpesvirinae subfamily of the Herpesviridae. These viruses …

After infection of skin or mucosa, herpes simplex virus enters the sensory nerve endings and
is conveyed by retrograde axonal transport to the dorsal root ganglion, where the virus …

Herpes virions consist of four morphologically distinct structures, a DNA core, capsid,
tegument, and envelope. Tegument occupies the space between the nucleocapsid (capsid …

The capsids of neurotropic herpesviruses have the remarkable ability to move in specific
directions within axons. By modulating bidirectional capsid transport to favor either …