Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion
formation methods and to preserve the stability of carriers in liquid media. The deposition of …

The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …

Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

The role in human health of therapeutic proteins in general, and monoclonal antibodies
(mAbs) in particular, has been significant and is continuously evolving. A considerable …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Proteins as amphiphilic, surface-active macromolecules, demonstrate substantial interfacial
activity, which causes considerable impact on their multifarious applications. A commonly …

Therapeutic antibodies and antibody derivatives comprise the majority of today's
biotherapeutics. Routine methods to generate novel antibodies, such as immunization and …

Biotherapeutic protein formulations are often high concentration liquid protein solutions,
which are required to be stable under pharmaceutically relevant storage conditions and …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

The presence of particles is a major issue during therapeutic protein formulation
development. Both proteinaceous and nonproteinaceous particles need to be analyzed not …