Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Background Old age is characterized by a peculiar low-grade, chronic, and “sterile”
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …

AMPK is an important kinase regulating energy homeostasis and also a key protein involved
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …

Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and
immune systems), which preserve the organism's health. We propose that the age-related …

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …

Intermittent fasting (IF) plays an essential role in improving lipid metabolism disorders
caused by metabolic cardiomyopathy. Growing evidence revealed that N6-methyladenosine …

Old age is associated with a greater burden of disease, including neurodegenerative
disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic …

Experimental trials in organisms ranging from yeast to humans have shown that various
forms of reducing food intake (caloric restriction) appear to increase both overall and healthy …