The human collectin, mannose‐binding lectin (MBL), is an important protein of the humoral
innate immune system. With multiple carbohydrate‐recognition domains, it is able to bind to …

Genetic epidemiology, including twin studies, provides robust evidence that genetic
variation in human populations contributes to susceptibility to infectious disease. One of the …

Mannan-binding lectin (MBL) deficiency has been classified as a commonly occurring
immune disorder, affecting approximately 30% of the human population. MBL, being part of …

The complement system plays an important role in mediating both acquired and innate
responses to defend against microbial infection, and in disposing immunoglobins and …

West Nile virus (WNV) causes a severe infection of the central nervous system in several
vertebrate animals including humans. Prior studies have shown that complement plays a …

Little is known of the role of human leucocyte antigen (HLA) alleles or non-HLA alleles in
determining resistance, susceptibility or the severity of acute viral infections. Dengue fever …

The immune response to hepatitis B vaccination differs greatly among individuals, with 5–
10% of healthy people failing to produce protective levels of antibodies. Several factors have …

Clinical and molecular characterization by Whole Exome Sequencing (WES) is reported in
35 COVID-19 patients attending the University Hospital in Siena, Italy, from April 7 to May 7 …

Complement, an important effector mechanism of the immune system, is an enzymatic
cascade of approx. 30 serum proteins leading to the amplification of a specific humoral …

Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell
response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test …