Platelet-derived growth factor (PDGF) isoforms play a major role in stimulating the
replication, survival, and migration of myofibroblasts during the pathogenesis of fibrotic …

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …

Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …

Recent advances in genetic manipulation have greatly expanded our understanding of
cellular responses to platelet-derived growth factors (PDGFs) during animal development. In …

Background It has been suggested that the presence of emphysema modifies the outcome
of patients with idiopathic pulmonary fibrosis (IPF). In this article we compare clinical …

Background Early detection and treatment for interstitial lung disease (ILD) in patients with
rheumatoid arthritis (RA) may ameliorate disease progression. The objective of this study …

Genetic analyses in mice have contributed significantly to the understanding of the
physiological functions of platelet-derived growth factors (PDGFs) and their receptors …

Pulmonary fibrosis is the consequence of a variety of diseases with no satisfying treatment
option. Therapy-induced fibrosis also limits the efficacy of chemotherapy and radiotherapy in …

Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for
connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF …

Substantial challenges remain in our understanding of fibrotic lung diseases. Nowhere is
this more true than in the elucidation and verification of the pathogenetic basis upon which …