Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Intestinal mucosal barrier function is the capacity of the intestine to provide adequate
containment of luminal microorganisms and molecules while preserving the ability to absorb …

Microbiota play critical roles in regulating colitis and colorectal cancer (CRC). However, it is
unclear how the microbiota generate protective immunity against these disease states. Here …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been
suggested to downregulate the production of inflammatory cytokines, but its physiological …

Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

Ubiquitylation is a widely used post-translational protein modification that regulates many
biological processes, including immune responses. The role of ubiquitin in immune …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …

Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory
disorders, partly due to their immunosuppressive properties. Although interleukin-1β (IL-1β) …