The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
S Pellegrini, I Dusanter‐Fourt - European journal of …, 1997 - Wiley Online Library
Since the discovery of their physiological roles in cytokine signalling, the Janus kinases
(JAKs) and the signal transducers and activators of transcription (STATs) have attracted …
(JAKs) and the signal transducers and activators of transcription (STATs) have attracted …
Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
RP de Groot, PJ Coffer, L Koenderman - Cellular signalling, 1998 - Elsevier
The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric
complex of a cytokine-specific α chain and a common β chain (βc). Binding of IL-3/IL-5/GM …
complex of a cytokine-specific α chain and a common β chain (βc). Binding of IL-3/IL-5/GM …
Observation of Bose-Einstein condensation in a dilute atomic vapor
MH Anderson, JR Ensher, MR Matthews, CE Wieman… - science, 1995 - science.org
A Bose-Einstein condensate was produced in a vapor of rubidium-87 atoms that was
confined by magnetic fields and evaporatively cooled. The condensate fraction first …
confined by magnetic fields and evaporatively cooled. The condensate fraction first …
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
JX Lin, TS Migone, M Tseng, M Friedmann… - Immunity, 1995 - cell.com
To understand the molecular bases for cytoklne redundancy and pleiotropy, we have
compared the Stat proteins activated in perlpheml blood lymphocytes (PBLs) by cytokines …
compared the Stat proteins activated in perlpheml blood lymphocytes (PBLs) by cytokines …
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
N Meydan, T Grunberger, H Dadi, M Shahar, E Arpaia… - Nature, 1996 - nature.com
ACUTE lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Despite
the progress achieved in its treatment, 20% of cases relapse and no longer respond to …
the progress achieved in its treatment, 20% of cases relapse and no longer respond to …
P210 and P190BCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
RL Ilaria, RA Van Etten - Journal of Biological Chemistry, 1996 - ASBMB
The products of the Philadelphia chromosome translocation, P210 and P190 BCR/ABL, are
cytoplasmic protein tyrosine kinases that share the ability to transform hematopoietic …
cytoplasmic protein tyrosine kinases that share the ability to transform hematopoietic …
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.
JA Johnston, CM Bacon, DS Finbloom… - Proceedings of the …, 1995 - National Acad Sciences
The cytokines interleukin 2 (IL-2) and IL-15 have similar biological effects on T cells and
bind common hematopoietin receptor subunits. Pathways that involve Janus kinases (JAKs) …
bind common hematopoietin receptor subunits. Pathways that involve Janus kinases (JAKs) …
Interleukin‐3, granulocyte‐macrophage colony stimulating factor and interleukin‐5 transduce signals through two STAT5 homologs.
AL Mui, H Wakao, AM O'farrell, N Harada… - The EMBO …, 1995 - embopress.org
Interleukin‐3 (IL‐3) is an important regulator of hemopoiesis and considerable effort has
been directed towards the study of its mechanism of signal transduction. In this paper, we …
been directed towards the study of its mechanism of signal transduction. In this paper, we …
Requirement of serine phosphorylation for formation of STAT-promoter complexes
X Zhang, J Blenis, HC Li, C Schindler, S Chen-Kiang - Science, 1995 - science.org
Members of the interleukin-6 family of cytokines bind to and activate receptors that contain a
common subunit, gp130. This leads to the activation of Stat3 and Stat1, two cytoplasmic …
common subunit, gp130. This leads to the activation of Stat3 and Stat1, two cytoplasmic …
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
By searching a database of expressed sequences, we identified a member of the signal
transducers and activators of transcription (Stat) family of proteins. Human and murine full …
transducers and activators of transcription (Stat) family of proteins. Human and murine full …