The amygdala is a structure of the temporal lobe thought to be involved in assigning
emotional significance to environmental information and triggering adapted physiological …

The medial division of the central nucleus of the amygdala (CeAM) and the lateral division of
the bed nucleus of the stria terminalis (BNSTL) are closely related. Both receive projections …

Chronic pain patients often develop mental disorders, and anxiety disorders are common.
We hypothesize that the comorbid anxiety results from an imbalance between the reward …

Clinical evidence suggests comorbidity between depression and irritable bowel syndrome
(IBS). Early-life stress and genetic predisposition are key factors in the pathophysiology of …

The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-
induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …

Pain is a complex experience composed of sensory and affective components. Although the
neural systems of the sensory component of pain have been studied extensively, those of its …

The interaction between the endocannabinoid system and catecholaminergic circuits has
gained increasing attention as it is recognized that the development of synthetic …

Glutamate, catecholamine and neuropeptide signaling within the bed nucleus of the stria
terminalis (BNST) have all been identified as key participants in anxiety-like behaviors and …

Methamphetamine (METH) is a psychostimulant that primarily exerts its effects on the
catecholamine (dopamine (DA) and norepinephrine (NE)) systems, which are implicated in …