The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Given that protein–protein interactions (PPIs) regulate nearly every living process; the
exploration of global and pathway-specific protein interaction networks is expected to have …

Cancer is a complex and heterogeneous disease that exhibits high levels of robustness
against various therapeutic interventions. It is a constellation of diverse and evolving …

Bone tissue remodels throughout life in response to mechanical loads. Impaired activities of
bone cells (osteocytes, osteoblasts and osteoclasts) result in a disruption of the bone …

Conditional control of plant cell function and development relies on appropriate signal
perception, signal integration and processing. The development of high throughput …

Abstract Background High-throughput RNAi screening is widely applied in biological
research, but remains expensive, infrastructure-intensive and conversion of many assays to …

A diverse series of mammalian two-hybrid technologies for the detection of protein–protein
interactions have emerged in the past few years, complementing the established yeast two …

This chapter will discuss the recent literature of macrocycles and drug-like property space
moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this …

Background Insight into protein–protein interactions (PPIs) is highly desirable in order to
understand the physiology of cellular events. This understanding is one of the challenges in …

Insect-derived antifungal peptides have a significant economic potential, particularly for the
engineering of pathogen-resistant crops. However, the nonspecific antifungal activity of such …