Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

Functional kainate receptors are ubiquitous in the central nervous system. After a search for
their functional significance, a considerable amount of data indicates that this class of …

ABSTRACT Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-
transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called …

Excitatory glutamatergic transmission involves a variety of different receptor types, each with
distinct properties and functions. Physiological studies have identified both post-and …

Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to
induce behavioral and electrophysiological seizures as well as neuropathological lesions …

A decade ago, our understanding of the molecular properties of kainate receptors and their
involvement in synaptic physiology was essentially null. A plethora of recent studies has …

Disorders of the central nervous system (CNS) are complex disease states that represent a
major challenge for modern medicine. Although aetilogy is often unknown, it is established …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …