The presence of emerging contaminants in the environment, such as pharmaceuticals, is a
growing global concern. The excessive use of medication globally, together with the …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter
(OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health …

BACKGROUND Analgesia during pregnancy is often necessary. Due to their widespread
availability, many mothers opt to use over-the-counter (OTC) analgesics. Those analgesic …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Concern has been raised over increased male reproductive disorders in the Western world,
and the disruption of male endocrinology has been suggested to play a central role. Several …

BACKGROUND Overall, the incidence of male reproductive disorders has increased in
recent decades. Testicular development during fetal life is crucial for subsequent male …

Background: Numerous chemicals are capable of disrupting androgen production, but the
possibility that they might act together to produce effects greater than those of the most …

Sex-specific gonadal differentiation is initiated by the expression of SRY in male foetuses.
This promotes a signalling pathway directing testicular development, while in female …

STUDY QUESTION Does ibuprofen use during the first trimester of pregnancy interfere with
the development of the human fetal ovary? SUMMARY ANSWER In human fetuses …