Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

Abstract Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the
maturation of the 5′ end of transfer RNA (tRNA). Although it carries out a biochemically …

RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

Ribonuclease (RNase) P is the universal ribozyme responsible for 5′-end tRNA
processing. We report the crystal structure of the Thermotoga maritima RNase P …

MutL and its homologs are essential for DNA mismatch repair. Mutations in genes encoding
human homologs of MutL cause multiorgan cancer susceptibility. We have determined the …

Type IIA topoisomerases both manage the topological state of chromosomal DNA and are
the targets of a variety of clinical agents. Bisdioxopiperazines are anticancer agents that …

Even though Bacillus subtilis is one of the most studied organisms, no function has been
identified for about 20% of its proteins. Among these unknown proteins are several RNA-and …

Ribonuclease P (RNase P) is an endonuclease involved in processing tRNA. It contains
both RNA and protein subunits and occurs in all three domains of life: namely, Archaea …

Abstract Background: Polynucleotide phosphorylase (PNPase) is a polyribonucleotide
nucleotidyl transferase (EC 2.7. 7.8) that degrades mRNA in prokaryotes. Streptomyces …

Transfer RNA is an essential adapter molecule that is found across all three domains of life.
The primary role of transfer RNA resides in its critical involvement in the accurate translation …