CAR-T cell therapy in hematological malignancies: current opportunities and challenges

X Zhang, L Zhu, H Zhang, S Chen, Y Xiao - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer
treatment, and it has achieved unprecedented success in hematological malignancies …

[HTML][HTML] Advancements in personalized CAR-T therapy: comprehensive overview of biomarkers and therapeutic targets in hematological malignancies

W Olejarz, K Sadowski, D Szulczyk… - International Journal of …, 2024 - mdpi.com
Chimeric antigen receptor T-cell (CAR-T) therapy is a novel anticancer therapy using
autologous or allogeneic T-cells. To date, six CAR-T therapies for specific B-cell acute …

Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics

W Liu, A Puri, D Fu, L Chen, C Wang, M Kellis… - Clinical & Experimental …, 2024 - Springer
Cancer is a disease that undergoes selective pressure to evolve during its progression,
becoming increasingly heterogeneous. Tumoral heterogeneity can dictate therapeutic …

[HTML][HTML] Applications of Multimodal Artificial Intelligence in Non-Hodgkin Lymphoma B Cells

P Isavand, SS Aghamiri, R Amin - Biomedicines, 2024 - mdpi.com
Given advancements in large-scale data and AI, integrating multimodal artificial intelligence
into cancer research can enhance our understanding of tumor behavior by simultaneously …

Regulatory T cells (Tregs) in lymphoid malignancies and the impact of novel therapies

K Maharaj, A Uriepero, E Sahakian… - Frontiers in …, 2022 - frontiersin.org
Regulatory T cells (Tregs) are responsible for maintaining immune homeostasis by
controlling immune responses. They can be characterized by concomitant expression of …

A glycolysis-related gene signatures in diffuse large B-Cell lymphoma predicts prognosis and tumor immune microenvironment

Y Cui, C Leng - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma
which that highly aggressive and heterogeneous. Glycolysis has been implicated in the …

The current socioeconomic and regulatory landscape of immune effector cell therapies

C Sainatham, D Yadav, A Dilli Babu… - Frontiers in …, 2024 - frontiersin.org
Immune cell effector therapies, including chimeric antigen receptor (CAR)-T cells, T-cell
receptor (TCR) T cells, natural killer (NK) cells, and macrophage-based therapies, represent …

Molecular characterization of primary mediastinal large B-cell lymphomas

M Donzel, F Pesce, A Trecourt, R Groussel, E Bachy… - Cancers, 2023 - mdpi.com
Simple Summary The present study describes a primary mediastinal large B-cell lymphoma
(PMBL) cohort on the morphological, immunohistochemical, and molecular levels, allowing …

Immune checkpoint inhibitors therapy as the game-changing approach for pediatric lymphoma: A brief landscape

S Ebrahimi, A Habibzadeh, S Khojasteh-Kaffash… - Critical Reviews in …, 2024 - Elsevier
Lymphoma is known as the third most common malignancy in children, and its prevalence
and mortality are increasing. Common treatments, including chemotherapy, radiotherapy …

The role of the gut microbiome in hematological cancers

N Hussein, R Rajasuriar, AM Khan, YAL Lim… - Molecular Cancer …, 2024 - AACR
Humans are in a complex symbiotic relationship with a wide range of microbial organisms,
including bacteria, viruses, and fungi. The evolution and composition of the human …