Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex
1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses …

The insulin/insulin-like growth factor signaling pathway is an evolutionary conserved
pathway across metazoans and is required for development, metabolism and behavior. This …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Current biochemical approaches have only identified the most well-characterized kinases
for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites …

During aging, preservation of locomotion is generally considered an indicator of sustained
good health, in elderlies and in animal models. In Caenorhabditis elegans, mutants of the …

Accurate prediction of post-translational modifications (PTMs) is of great significance in
understanding cellular processes, by modulating protein structure and dynamics …

Background Aging is characterized by a general decline in cellular function, which ultimately
affects whole body homeostasis. This study aimed to investigate the effects and underlying …