Design challenges in polymeric scaffolds for tissue engineering

MI Echeverria Molina, KG Malollari… - … in Bioengineering and …, 2021 - frontiersin.org
Numerous surgical procedures are daily performed worldwide to replace and repair
damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged …

Regenerative medicine therapies for targeting neuroinflammation after stroke

O Rajkovic, G Potjewyd, E Pinteaux - Frontiers in neurology, 2018 - frontiersin.org
Inflammation is a major pathological event following ischemic stroke that contributes to
secondary brain tissue damage leading to poor functional recovery. Following the initial …

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

RD Bartlett, D Eleftheriadou, R Evans, D Choi… - Biomaterials, 2020 - Elsevier
Disorders affecting the central nervous system are a leading cause of disability in the world.
Regenerative medicine using biomaterial-based therapies is a growing field that has …

Neurorepair and regeneration of the brain: a decade of bioscaffolds and engineered microtissue

LN Zamproni, MTVV Mundim… - Frontiers in cell and …, 2021 - frontiersin.org
Repairing the human brain remains a challenge, despite the advances in the knowledge of
inflammatory response to injuries and the discovery of adult neurogenesis. After brain injury …

Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains

MH Hettiaratchi, MJ O'Meara, CJ Teal, SL Payne… - Journal of controlled …, 2019 - Elsevier
Central nervous system (CNS) injuries, such as stroke and spinal cord injuries, result in the
formation of a proteoglycan-rich glial scar, which acts as a barrier to axonal regrowth and …

[HTML][HTML] The potential of biomaterials for central nervous system cellular repair

S Jarrin, S Cabre, E Dowd - Neurochemistry International, 2021 - Elsevier
The central nervous system (CNS) can be injured or damaged through a variety of insults
including traumatic injury, stroke, and neurodegenerative or demyelinating diseases …

Harnessing stem cells and biomaterials to promote neural repair

KF Bruggeman, N Moriarty, E Dowd… - British journal of …, 2019 - Wiley Online Library
With the limited capacity for self‐repair in the adult CNS, efforts to stimulate quiescent stem
cell populations within discrete brain regions, as well as harness the potential of stem cell …

Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain

SL Payne, A Tuladhar, JM Obermeyer, BV Varga… - Biomaterials, 2019 - Elsevier
Ischemic stroke results in a loss of neurons for which there are no available clinical
strategies to stimulate regeneration. While preclinical studies have demonstrated that …

Development of an in situ injectable hydrogel containing hyaluronic acid for neural regeneration

LTB Nguyen, CC Hsu, H Ye, Z Cui - Biomedical Materials, 2020 - iopscience.iop.org
In this work, a novel enzymatically crosslinked injectable hydrogel comprising hyaluronic
acid (HyA), dopamine (DA), and 3-(4-hydroxyphenyl) propionic acid (HPA) conjugates was …

Taking central nervous system regenerative therapies to the clinic: curing rodents: versus: nonhuman primates: versus: humans

M Tsintou, K Dalamagkas, N Makris - Neural Regeneration …, 2020 - journals.lww.com
The central nervous system is known to have limited regenerative capacity. Not only does
this halt the human body's reparative processes after central nervous system lesions, but it …