The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Cl− is the major extracellular (Cl− out) and intracellular (Cl− in) anion whose concentration
is actively regulated by multiple transporters. These transporters generate Cl− gradients …

Abstract SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune
responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense …

Abstracts Airway epithelial cells harbor the capacity of active Cl− transepithelial transport
and play critical roles in modulating innate immunity. However, whether intracellular Cl …

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary
diseases. Cigarette consumption is the main cause for development of COPD, while CF is …

Despite its significant overexpression in several malignant neoplasms, the expression of
RPS27 in the central nervous system (CNS) is widely unknown. We identified the cell types …

The impairment of the cystic fibrosis transmembrane conductance regulator (CFTR) activity
induces intracellular chloride (Cl–) accumulation. The anion Cl–, acting as a second …

Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is
characterized by high NaCl concentration in sweat and the production of a thick and sticky …

The impairment of the CFTR channel activity, a cAMP-activated chloride (Cl−) channel
responsible for cystic fibrosis (CF), has been associated with a variety of mitochondrial …

In the present work, microgels were utilized as a cell-free reaction environment to produce a
functional malonyl-CoA synthetase (deGFP-MatB) under geometry-controlled transcription …