Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

L Mashouri, H Yousefi, AR Aref, A Ahadi, F Molaei… - Molecular cancer, 2019 - Springer
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer
processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion …

Glutathione S-transferases in cancer

RR Singh, KM Reindl - Antioxidants, 2021 - mdpi.com
In humans, the glutathione S-transferases (GST) protein family is composed of seven
members that present remarkable structural similarity and some degree of overlapping …

[HTML][HTML] Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer

B Bueschbell, AB Caniceiro, PMS Suzano… - Drug Resistance …, 2022 - Elsevier
Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and developing regions …

The genetic vulnerability to cisplatin ototoxicity: a systematic review

E Tserga, T Nandwani, NK Edvall, J Bulla, P Patel… - Scientific reports, 2019 - nature.com
Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular
cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has …

Overexpression of glutathione S-transferases in human diseases: Drug targets and therapeutic implications

N Lv, C Huang, H Huang, Z Dong, X Chen, C Lu… - Antioxidants, 2023 - mdpi.com
Glutathione S-transferases (GSTs) are a major class of phase II metabolic enzymes. Besides
their essential role in detoxification, GSTs also exert diverse biological activities in the …

LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on …

G Li, Y Cai, C Wang, M Huang, J Chen - Journal of neuro-oncology, 2019 - Springer
Introduction To investigate the effects of lncRNA GAS5 on the proliferation, migration,
invasion and apoptosis of brain glioma cells. Methods The expression levels of lncRNA …

An effective method of isolating honey proteins

A Bocian, J Buczkowicz, M Jaromin, KK Hus, J Legáth - Molecules, 2019 - mdpi.com
Honey is a natural sweetener composed mostly of sugars, but it contains also pollen grains,
proteins, free amino acids, and minerals. The amounts and proportions of these components …

Glutathione S-transferase M3 is associated with glycolysis in intrinsic temozolomide-resistant glioblastoma multiforme cells

SY Cheng, NF Chen, ZH Wen, ZK Yao, KH Tsui… - International Journal of …, 2021 - mdpi.com
Glioblastoma multiforme (GBM) is a malignant primary brain tumor. The 5-year relative
survival rate of patients with GBM remains< 30% on average despite aggressive treatments …

Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction

MK Elgohary, MS Elkotamy, T Al-Warhi… - Bioorganic …, 2024 - Elsevier
LSM-83177, a phenoxy acetic acid derivative, is a small molecule reported for its promising
anti-tumor properties. Via inhibiting the interaction between MDM2 and p53, LSM-83177 can …

GSTM3 function and polymorphism in cancer: emerging but promising

S Wang, J Yang, L You, M Dai… - Cancer management and …, 2020 - Taylor & Francis
Cancer is a major cause of human mortality; however, the molecular mechanisms and
proteomic biomarkers that cause tumor progression in malignant tumors are either unknown …