The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

Pseudogenes have long been labeled as “junk” DNA, failed copies of genes that arise
during the evolution of genomes. However, recent results are challenging this moniker; …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

Expression of Snail1 in epithelial cells triggers an epithelial–mesenchymal transition (EMT).
Here, we demonstrate that the synthesis of Zeb2, a transcriptional repressor of E-cadherin, is …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

By analyzing 1,780,295 5′-end sequences of human full-length cDNAs derived from 164
kinds of oligo-cap cDNA libraries, we identified 269,774 independent positions of …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

We describe a new method, Tag-seq, which employs ultra high-throughput sequencing of 21
base pair cDNA tags for sensitive and cost-effective gene expression profiling. We …

Many genomic loci contain transcription units on both strands, therefore two oppositely
oriented transcripts can overlap. Often, one strand codes for a protein, whereas the transcript …

Mammalian genomes harbor a larger than expected number of complex loci, in which
multiple genes are coupled by shared transcribed regions in antisense orientation and/or by …