Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

R Hardeland - Journal of pineal research, 2013 - Wiley Online Library
The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

The role of dietary histone deacetylases (HDACs) inhibitors in health and disease

SA Bassett, MPG Barnett - Nutrients, 2014 - mdpi.com
Modification of the histone proteins associated with DNA is an important process in the
epigenetic regulation of DNA structure and function. There are several known modifications …

Epigenetic regulation of female puberty

A Lomniczi, H Wright, SR Ojeda - Frontiers in Neuroendocrinology, 2015 - Elsevier
Substantial progress has been made in recent years toward deciphering the molecular and
genetic underpinnings of the pubertal process. The availability of powerful new methods to …

Formononetin treatment in type 2 diabetic rats reduces insulin resistance and hyperglycemia

MJ Oza, YA Kulkarni - Frontiers in pharmacology, 2018 - frontiersin.org
Type 2 diabetic mellitus is a multifactorial metabolic disorder affecting huge population
around the world. This indicates that there is an urgent unmet need of cost effective, new …

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases

Y Zhang, S Anoopkumar-Dukie, D Arora… - European journal of …, 2020 - Elsevier
Neurodegenerative disease refers to a range of chronic and progressive disorders that are
characterized by dysfunction and loss of neurons. Neurodegeneration involves protein …

The role of altered protein acetylation in neurodegenerative disease

F Kabir, R Atkinson, AL Cook, AJ Phipps… - Frontiers in Aging …, 2023 - frontiersin.org
Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

miRNA in Parkinson's disease: From pathogenesis to theranostic approaches

A Elangovan, D Venkatesan, P Selvaraj… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is an age associated neurological disorder which is specified by
cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non …

The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus

P Šimják, A Cinkajzlová, K Anderlová… - Journal of …, 2018 - joe.bioscientifica.com
Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third
trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most …

Obesity and male reproduction: do sirtuins play a role?

F Barbagallo, S La Vignera, R Cannarella… - International journal of …, 2022 - mdpi.com
Obesity is a major current public health problem of global significance. A progressive sperm
quality decline, and a decline in male fertility, have been reported in recent decades …

Emerging genetic and epigenetic mechanisms underlying pubertal maturation in adolescence

CF Aylwin, CA Toro, E Shirtcliff… - Journal of Research on …, 2019 - Wiley Online Library
The adolescent transition begins with the onset of puberty which, upstream in the brain, is
initiated by the gonadotropin‐releasing hormone (Gn RH) pulse generator that activates the …