New insights on pharmacological and therapeutic potentials of trimetazidine beyond anti-anginal drug: A comprehensive review

D Singh, J Oladimeji-Salami, AJ Akindele - European Journal of …, 2024 - Elsevier
Trimetazidine (TMZ) is a beneficial and well-tolerable anti-anginal drug which has protective
action towards ischemia and reperfusion injury. TMZ performs its anti-ischemic effect by …

Evaluating the protective role of trimetazidine versus nano-trimetazidine in amelioration of bilateral renal ischemia/reperfusion induced neuro-degeneration …

FE Hassan, BE Aboulhoda, IH Ali, HM Elwi, LM Matter… - Tissue and Cell, 2023 - Elsevier
Background Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury.
Neurodegeneration can result from I/R, but the mechanisms are still challenging. We studied …

[PDF][PDF] Trimetazidine attenuates neuroinflammation via TLR4/NF-KB

NS Mahmoud, MA Elbaset, OA Mohawed… - J. Appl. Pharm …, 2024 - academia.edu
Neurodegenerative dementia impairs mental ability and short-term memory. This study
investigated the effectiveness of trimetazidine (TMZ) in mitigating lipopolysaccharides …

[HTML][HTML] Protective effect of hesperidin on malathion-induced ovarian toxicity in mice: The role of miRNAs, inflammation, and apoptosis

SF Talebi, A Kooshki, M Zarein, M Seify, B Dolatshahi… - Toxicology Reports, 2024 - Elsevier
Malathion, a widely used organophosphate, is known for its relatively low toxicity and
extensive application. However, it has been found to act as a female reproductive toxicant by …

Hesperidin attenuates radiation-induced ovarian failure in rats: Emphasis on TLR-4/NF-ĸB signaling pathway

DH Mohamed, RS Said, DH Kassem, AM Gad… - Toxicology and Applied …, 2024 - Elsevier
Young women suffering from premature ovarian failure after radiotherapy carry a huge
burden in the field of cancer therapy including reproductive loss, emotional stress, and …

Neuropeptide W protects against ovarian oxidative injury and reinforces ovarian steroidogenic activity via the upregulation of ERα expression

S Arabacı Tamer, LS Şen, K Güneş… - Journal of Pharmacy …, 2024 - academic.oup.com
Objectives The aim of this study was to investigate the protective effect of neuropeptide W
(NPW) on ovarian ischemia–reperfusion-induced oxidative injury and ovarian steroid …

[HTML][HTML] Effect of trimetazidine against ovarian ischemia/reperfusion injury in rat model: A new pathway: JAK2/STAT3

TN Yuksel, Z Halici, E Cadirci, E Toktay… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): Ovarian ischemia/reperfusion (I/R) is an extremely complex pathological
problem that begins with oxygen deprivation, progresses to excessive free radical …

Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation

D Mutailifu, A Aini, A Aibibula, Z Liu… - Journal of Visualized …, 2025 - app.jove.com
The objective of this study was to investigate the cardioprotective effects of Munziq on
abnormal body fluid myocardial ischemia-reperfusion injury (MIRI) and its underlying …

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

A Yurci, F Zaman, U Sarı, E Deveci - Acta Cirúrgica Brasileira, 2024 - SciELO Brasil
Purpose: To investigate inflammation and cell adhesion molecules in the vagina after
ovarian ischemia-reperfusion (IR) injury. Methods: 20 Wistar albino female rats were divided …

The Effect of “Proanthocyanidin” on Ischemia–Reperfusion Injury in Skeletal Muscles of Rats

A Özer, B Koçak, ŞC Sezen, M Arslan, M Kavutçu - Medicina, 2024 - mdpi.com
Background and Objectives: Lower limb skeletal muscle ischemia–reperfusion (IR) injury is
associated with increased morbidity and mortality, and it is common in several clinical …