The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics,
it is imperative to explore avenues that breathe new life into existing drugs. This is …

The escalating rise in antimicrobial resistance (AMR) coupled with a declining arsenal of
new antibiotics is imposing serious threats to global public health. A pervasive aspect of …

Main observation and conclusion The limit ability of traditional antibiotics to treat drug
resistant bacteria calls for new therapeutic alternatives. A class of unique sulfanilamide …

A series of 2-aminothiazole sulfanilamide oximes were developed as new membrane active
antibacterial agents to conquer the microbial infection. Benzoyl derivative 10c was …

Gram-negative bacteria, especially the ones with multidrug resistance, post dire challenges
to antibiotic treatments due to the presence of the outer membrane (OM), which blocks the …

Gram-positive bacteria like Enterococcus faecium and Staphylococcus aureus, and Gram-
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

The rapid and persistent emergence of drug-resistant bacteria poses a looming public
health crisis. The possible task of developing new sets of antibiotics to replenish the existing …

Biofilms in burns are major problems: bacterial communities rapidly develop antibiotic
resistance, and 60% of burn mortality is attributed to biofilms. Key pathogens are …