Epigenetic signatures underlying inflammation: An interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

O Ramos-Lopez, FI Milagro, JI Riezu-Boj… - Inflammation …, 2021 - Springer
Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

P Dongiovanni, M Meroni, S Casati, R Goldoni… - International journal of …, 2023 - nature.com
Several chronic disorders including type 2 diabetes (T2D), obesity, heart disease and
cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early …

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc

V Madhu, M Hernandez-Meadows, PK Boneski, Y Qiu… - Autophagy, 2023 - Taylor & Francis
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …

Epigenetic alterations and inflammation as emerging use for the advancement of treatment in non-small cell lung cancer

S Yang, Y Huang, Q Zhao - Frontiers in Immunology, 2022 - frontiersin.org
Lung cancer remains one of the most common malignancies in the world. Nowadays, the
most common lung cancer is non-small cell lung cancer (NSCLC), namely …

Molecular basis of ageing in chronic metabolic diseases

R Spinelli, L Parrillo, M Longo, P Florese… - Journal of …, 2020 - Springer
Aim Over the last decades, the shift in age distribution towards older ages and the
progressive ageing which has occurred in most populations have been paralleled by a …

Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

Overview of the pathogenesis, genetic, and non-invasive clinical, biochemical, and scoring methods in the assessment of NAFLD

V Kupčová, M Fedelešová, J Bulas… - International journal of …, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease
worldwide. It represents a range of disorders, including simple steatosis, nonalcoholic …

Crosstalk between inflammatory signaling and methylation in cancer

D Das, N Karthik, R Taneja - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Inflammation is an intricate immune response against infection and tissue damage. While
the initial immune response is important for preventing tumorigenesis, chronic inflammation …

Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases

P Smolen, PK Dash, JB Redell - Frontiers in Neuroscience, 2023 - frontiersin.org
Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for
developing neurodegenerative diseases (NDs). However, molecular mechanisms that …

An exploratory pilot study of changes in global DNA methylation in patients undergoing major breast surgery under opioid-based general anesthesia

FF Caputi, L Carboni, L Rullo, I Alessandrini… - Frontiers in …, 2021 - frontiersin.org
This study aimed to investigate DNA methylation levels in patients undergoing major breast
surgery under opioid-based general anesthesia. Blood samples were collected from eleven …