Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of
the human motor system, first described in the 19th Century. The etiology of ALS appears to …

Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease,
characterized by the death of upper (UMN) and lower motor neurons (LMN) in the motor …

Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to
severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is …

Toxic proteinaceous deposits and alterations in excitability and activity levels characterize
vulnerable neuronal populations in neurodegenerative diseases. Using in vivo two-photon …

Amyotrophic lateral sclerosis (ALS) is a terminalneurodegenerative disease. Clinical and
molecular observations suggest that ALS pathology originates at a single site and spreads …

Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in
neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of both upper and lower motor neurons, resulting in muscle …

The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport
of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is …