Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors

M Farshbafnadi, SK Zonouzi, M Sabahi… - Experimental …, 2021 - Elsevier
Abstract The emergence of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-
2) in late 2019 has been associated with a high rate of mortality and morbidity. It has been …

[HTML][HTML] Role of genetic variants and gene expression in the susceptibility and severity of COVID-19

S Choudhary, K Sreenivasulu, P Mitra… - Annals of laboratory …, 2021 - synapse.koreamed.org
Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a …

miR-98 regulates TMPRSS2 expression in human endothelial cells: key implications for COVID-19

A Matarese, J Gambardella, C Sardu, G Santulli - Biomedicines, 2020 - mdpi.com
The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and …

Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19

S Senapati, P Banerjee, S Bhagavatula… - Journal of genetics, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an
emerging global public health crisis. Angiotensin converting enzyme 2 (ACE2) and trans …

Identification of natural inhibitors against SARS-CoV-2 drugable targets using molecular docking, molecular dynamics simulation, and MM-PBSA approach

PP Kushwaha, AK Singh, T Bansal, A Yadav… - Frontiers in cellular …, 2021 - frontiersin.org
The present study explores the SARS-CoV-2 drugable target inhibition efficacy of
phytochemicals from Indian medicinal plants using molecular docking, molecular dynamics …

Genetic and epigenetic factors associated with increased severity of Covid‐19

Z Yildirim, OS Sahin, S Yazar… - Cell biology …, 2021 - Wiley Online Library
Since December 2019, a new form of severe acute respiratory syndrome (SARS) from a
novel strain of coronavirus (SARS coronavirus 2 [SARS‐CoV‐2]) has been spreading …

TMPRSS2 polymorphism (rs12329760) and the severity of the COVID-19 in Iranian population

A Yaghoobi, JS Lord, JS Rezaiezadeh… - PLoS …, 2023 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for
the recent pandemic since early 2020. Due to the wide range of clinical symptoms of this …

Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control …

K Schönfelder, K Breuckmann, C Elsner… - Frontiers in …, 2021 - frontiersin.org
The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables
entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host …

Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection

SMA Hashemi, M Thijssen, SY Hosseini, A Tabarraei… - Archives of …, 2021 - Springer
The SARS-CoV-2 pandemic has become one of the most serious health concerns globally.
Although multiple vaccines have recently been approved for the prevention of coronavirus …

Organoid and microfluidics-based platforms for drug screening in COVID-19

R Ramezankhani, R Solhi, YC Chai, M Vosough… - Drug discovery today, 2022 - Elsevier
Highlights•Modelling platforms facilitate identification of therapeutic and prophylactic
approaches in COVID-19.•Genome based strategies and computational platforms have …