Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

The past decade has brought great strides in our understanding of adaptive immunity in
neonatal mice. Although poor immune responses are commonly observed, it is now clear …

Abstract Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required
for the development of T cells and for their persistence in the periphery. Unlike many other …

Delivery of macromolecules mediated by protein transduction domains (PTDs) attracts a lot
of interest due to its therapeutic and biotechnological potential. A major reevaluation of the …

The peripheral naive T cell pool is fairly stable in number, diversity and functional
competence in the absence of vigorous immune responses. However, this apparent …

The dependence of retroviral replication on cell proliferation was described as early as
1958, although different classes of retroviruses are able to infect non-dividing cells with …

Work in the past years has led to a refined phenotypical description of functionally distinct T-
and B-cell subsets. Since both lymphocyte compartments are established and undergo …

We investigated the relationship of memory CD4+ T cells with the evolution of influenza virus-
specific CD4+ T cell responses in healthy young and elderly people. Elderly individuals had …

Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with
antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent …

A major limitation of current lentiviral vectors (LVs) is their inability to govern efficient gene
transfer into quiescent cells such as primary T cells, which hampers their application for …