Genetic diseases seriously threaten human health and have always been one of the
refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA …

Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly
hampered by the lack of suitable disease models. Indeed, animal models do not faithfully …

Parkinson's disease (PD) affects millions of people worldwide, it dramatically affects the
brain areas' structure and functions. Therefore, it causes a progressive decline of cognitive …

Cell reprogramming is a groundbreaking technology that, in few decades, generated a new
paradigm in biomedical science. To date we can use cell reprogramming to potentially …

Parkinson's disease (PD) is a neurodegenerative disease still without any cure. Brain-
derived neurotrophic factor (BDNF) has shown therapeutic potential in PD, which is limited …

Parkinson's disease is a neurodegenerative disorder accompanied by depletion of
dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible …

The lack of regenerative capacity of neurons leads to poor prognoses for some neurological
disorders. The use of small molecules to directly reprogram somatic cells into neurons …

Rare monogenic disorders are a group of single-gene-mutated diseases that have a low
incidence rate (less than 0.5‰) and eventually lead to patient disability and even death. Due …

The relatively few dopaminergic neurons in the mammalian brain are mostly located in the
midbrain and regulate many important neural functions, including motor integration …