Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …

In the modern era, coronary artery disease (CAD) has become the most common form of
heart disease and, due to the severity of its clinical manifestations and its acute …

Introduction Gene identification for genetic diseases is critical for the development of new
diagnostic approaches and personalized treatment options. Prioritization of gene translation …

Aims Genome-wide association studies (GWASs) have discovered hundreds of common
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …

Objective: Carotid artery intima-media thickness (cIMT) is a widely accepted marker of
subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and …

Background Both genetic background and diet are important determinants of cardiovascular
diseases (CVD). Understanding gene-diet interactions could help improve CVD prevention …

Background: Hundreds of candidate genes have been associated with coronary artery
disease (CAD) through genome-wide association studies. However, a systematic way to …

Introduction Cardiovascular disease (CVD) is responsible for over 30% of mortality
worldwide. CVD arises from the complex influence of molecular, clinical, social, and …

Background: Atherosclerosis, one of the main threats to human life and health, is driven by
abnormal inflammation (ie, chronic inflammation or oxidative stress) during accelerated …

There are 90 independent genome-wide significant genetic risk variants for Parkinson's
disease (PD) but currently only five nominated loci for PD progression. The biology of PD …