Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence

Y Xu, GH Su, D Ma, Y Xiao, ZM Shao… - Signal Transduction and …, 2021 - nature.com
Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Evolution of CD8+ T Cell Receptor (TCR) Engineered Therapies for the Treatment of Cancer

Y Sun, F Li, H Sonnemann, KR Jackson, AH Talukder… - Cells, 2021 - mdpi.com
Engineered T cell receptor T (TCR-T) cell therapy has facilitated the generation of
increasingly reliable tumor antigen-specific adaptable cellular products for the treatment of …

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

G Ehx, JD Larouche, C Durette, JP Laverdure… - Immunity, 2021 - cell.com
Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly
because of the lack of actionable immune targets. Using an original proteogenomic …

Breast cancer immunopeptidomes contain numerous shared tumor antigens

E Kina, JP Laverdure, C Durette… - The Journal of …, 2024 - Am Soc Clin Investig
Hormone receptor–positive breast cancer (HR+) is immunologically cold and has not
benefited from advances in immunotherapy. In contrast, subsets of triple-negative breast …

BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens

MVR Cuevas, MP Hardy, JD Larouche, A Apavaloaei… - Genome Biology, 2023 - Springer
MHC-I-associated peptides deriving from non-coding genomic regions and mutations can
generate tumor-specific antigens, including neoantigens. Quantifying tumor-specific …

The human immunopeptidome project: a roadmap to predict and treat immune diseases

JA Vizcaíno, P Kubiniok, KA Kovalchik, Q Ma… - Molecular & Cellular …, 2020 - ASBMB
The science that investigates the ensembles of all peptides associated to human leukocyte
antigen (HLA) molecules is termed" immunopeptidomics" and is typically driven by mass …

Exploring the cancer-testis antigen BORIS to design a novel multi-epitope vaccine against breast cancer based on immunoinformatics approaches

E Mahdevar, A Safavi, A Abiri, A Kefayat… - Journal of …, 2022 - Taylor & Francis
Recently, cancer immunotherapy has gained lots of attention to replace the current
chemoradiation approaches and multi-epitope cancer vaccines are manifesting as the next …

Proteogenomics uncovers a vast repertoire of shared tumor-specific antigens in ovarian cancer

Q Zhao, JP Laverdure, J Lanoix, C Durette… - Cancer immunology …, 2020 - AACR
High-grade serous ovarian cancer (HGSC), the principal cause of death from gynecologic
malignancies in the world, has not significantly benefited from advances in cancer …

Personalized cancer vaccination in head and neck cancer

H Shibata, L Zhou, N Xu, AM Egloff… - Cancer …, 2021 - Wiley Online Library
Cancer is characterized by an accumulation of somatic mutations that represent a source of
neoantigens for targeting by antigen‐specific T cells. Head and neck squamous cell …

Extending the comprehensiveness of immunopeptidome analyses using isobaric peptide labeling

S Pfammatter, E Bonneil, J Lanoix, K Vincent… - Analytical …, 2020 - ACS Publications
Defining the repertoire of peptides presented by the major histocompatibility complex class I
(MHC I) is a key step toward the identification of relevant antigens for cancer …