Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia
(R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Neuroblastoma, the most frequent solid tumor in infants, shows very diverse outcomes from
spontaneous regression to fatal disease. When these different tumors originate and how …

Abstract KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Tumors are complex tissues of cancerous cells surrounded by a heterogeneous cellular
microenvironment with which they interact. Single-cell sequencing enables molecular …

Background Neuroblastoma is the most common solid tumor in infants accounting for
approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma …