Psychostimulant, cardiovascular, and temperature actions of stimulants involve adrenergic
(norepinephrine), dopaminergic (dopamine), and serotonergic (serotonin) pathways …

New psychoactive substances represent a public health threat since they are not controlled
by international conventions, are easily accessible online and are sold as a legal alternative …

New medicines containing classic hallucinogenic and entactogenic psychedelic substance
are under development for various psychiatric and neurological disorders. Many of these …

Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …

As recreational substances, synthetic cathinones started to be used at the beginning of the
21st century. There is still limited data on these compounds, introduced to the illicit drug …

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …

Chemsex and slamsex represent a serious public health concern that has to be considered
by both clinical and forensic toxicologists. Indeed, such practices appear to carry a …

In the present work an isocratic enantioselective high-performance liquid chromatography-
tandem mass spectrometry (LC-MS/MS) method was developed for the separation and …

Aim. Drug abuse and addiction are major public health concerns, with millions of people
worldwide affected by the negative consequences of drug use. To better understand this …

Several new synthetic cathinones, which mimic the effect of classical psychostimulants such
as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In …