Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …

Many cell types, including neurons, are known to release small membranous vesicles
known as exosomes. In addition to their protein content these vesicles have recently been …

The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the
infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we …

Prion diseases are fatal, transmissible neurodegenerative disorders associated with
conversion of the host‐encoded prion protein (PrPC) into an abnormal pathogenic isoform …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

The prion (infectious protein) concept has evolved with the discovery of new self-
propagating protein states in organisms as diverse as mammals and fungi. The infectious …

Exosomes are small membranous vesicles secreted by a number of cell types and can be
isolated from conditioned cell media or bodily fluids such as urine and plasma. Exosome …

Forty-three years have passed since it was first proposed that a protein could be the sole
component of the infectious agent responsible for the enigmatic prion diseases. Many …

Exosomes are small membrane‐bound vesicles released from cells and found in vivo in
most biological fluids. Functions reported for exosomes include cell–cell communication …

The conversion of the properly folded prion protein, PrPc, to its misfolded amyloid form,
PrPsc, occurs as the two proteins traffic along the endocytic pathway and PrPc is exposed to …