Exercise promotes healthy aging of skeletal muscle

GD Cartee, RT Hepple, MM Bamman, JR Zierath - Cell metabolism, 2016 - cell.com
Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Roles of TBC1D1 and TBC1D4 in insulin-and exercise-stimulated glucose transport of skeletal muscle

GD Cartee - Diabetologia, 2015 - Springer
This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1
Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 …

Enhanced muscle insulin sensitivity after contraction/exercise is mediated by AMPK

R Kjøbsted, N Munk-Hansen, JB Birk, M Foretz… - Diabetes, 2017 - Am Diabetes Assoc
Earlier studies have demonstrated that muscle insulin sensitivity to stimulate glucose uptake
is enhanced several hours after an acute bout of exercise. Using AICAR, we recently …

Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise

GD Cartee - American journal of physiology-endocrinology …, 2015 - journals.physiology.org
Enhanced skeletal muscle and whole body insulin sensitivity can persist for up to 24–48 h
after one exercise session. This review focuses on potential mechanisms for greater …

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner

R Kjøbsted, JT Treebak, J Fentz, L Lantier, B Viollet… - Diabetes, 2015 - Am Diabetes Assoc
An acute bout of exercise increases glucose uptake in skeletal muscle by an insulin-
independent mechanism. In the period after exercise, insulin sensitivity to increased glucose …

Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant …

CM Castorena, EB Arias, N Sharma, GD Cartee - Diabetes, 2014 - Am Diabetes Assoc
Earlier research on rats with normal insulin sensitivity demonstrated that acute exercise
increased insulin-stimulated glucose uptake (GU) concomitant with greater phosphorylation …

TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction

R Kjøbsted, JM Kristensen, NO Eskesen, K Kido… - Diabetes, 2023 - Am Diabetes Assoc
The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-
body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the …

Post-translational modifications: the signals at the intersection of exercise, glucose uptake, and insulin sensitivity

B Stocks, JR Zierath - Endocrine reviews, 2022 - academic.oup.com
Diabetes is a global epidemic, of which type 2 diabetes makes up the majority of cases.
Nonetheless, for some individuals, type 2 diabetes is eminently preventable and treatable …

Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia …

JP Raja Xavier, T Okumura, M Apweiler, NA Chacko… - Biological Research, 2024 - Springer
After menstruation the uterine spiral arteries are repaired through angiogenesis. This
process is tightly regulated by the paracrine communication between endometrial stromal …

Exercise-induced improvement in insulin-stimulated glucose uptake by rat skeletal muscle is absent in male AS160-knockout rats, partially restored by muscle …

A Zheng, EB Arias, H Wang, SE Kwak, X Pan… - Diabetes, 2022 - Am Diabetes Assoc
One exercise session can elevate insulin-stimulated glucose uptake (ISGU) in skeletal
muscle, but the mechanisms remain elusive. Circumstantial evidence suggests a role for Akt …