Challenges and best practices in omics benchmarking
TG Brooks, NF Lahens, A Mrčela, GR Grant - Nature Reviews Genetics, 2024 - nature.com
Technological advances enabling massively parallel measurement of biological features—
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …
A compendium of methods: Searching allele specific expression via RNA sequencing
Diploid mammalian genome has paired alleles for each gene; typically allowing for equal
expression of the two alleles within the cell/tissue. However, genetic regulatory elements …
expression of the two alleles within the cell/tissue. However, genetic regulatory elements …
Haplotype-aware multiomics unveils the regulatory basis of haplodiplontic life-cycle differentiation in a cosmopolitan marine alga
Gephyrocapsa huxleyi (formerly Emiliania huxleyi), a key coccolithophore alga influencing
the global carbon cycle through photosynthesis and calcification, undergoes a …
the global carbon cycle through photosynthesis and calcification, undergoes a …
Context Dependent Perturbation of Allelic Expression Imbalance Reveals Novel Candidate Therapeutic Targets for Metabolic diseases
S Moon, SY Park - bioRxiv, 2023 - biorxiv.org
Background Obesity is a pivotal trigger for a spectrum of complex metabolic disorders. By
colocalizing cis-eQTLs in adipose tissues from the GTEx consortium and trait-associated …
colocalizing cis-eQTLs in adipose tissues from the GTEx consortium and trait-associated …
Integrating nanopore long-range genomic variant phasing to improve resolution of allele-specific expression from short-read RNA-seq
KMG Chang - 2023 - open.library.ubc.ca
Cancer genomes often carry somatic mutations that disrupt gene expression on specific
alleles, leading to Allele-Specific Expression (ASE). ASE may dysregulate cancer driver …
alleles, leading to Allele-Specific Expression (ASE). ASE may dysregulate cancer driver …