[HTML][HTML] Software tools and approaches for compound identification of LC-MS/MS data in metabolomics

I Blaženović, T Kind, J Ji, O Fiehn - Metabolites, 2018 - mdpi.com
The annotation of small molecules remains a major challenge in untargeted mass
spectrometry-based metabolomics. We here critically discuss structured elucidation …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

[HTML][HTML] Advances in mass spectrometry-based metabolomics for investigation of metabolites

JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …

Current approaches and challenges for the metabolite profiling of complex natural extracts

JL Wolfender, G Marti, A Thomas, S Bertrand - Journal of Chromatography …, 2015 - Elsevier
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

[HTML][HTML] Ion mobility-mass spectrometry: time-dispersive instrumentation

JC May, JA McLean - Analytical chemistry, 2015 - ACS Publications
The field of ion mobility-mass spectrometry (IM-MS) has grown with significant momentum in
recent years in both fundamental advances and pioneering applications. A search of the …

Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry

G Paglia, G Astarita - Nature protocols, 2017 - nature.com
Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …

Catalyst-free Highly Sensitive SnO2 Nanosheet Gas Sensors for Parts per Billion-Level Detection of Acetone

K Kim, PG Choi, T Itoh, Y Masuda - ACS Applied Materials & …, 2020 - ACS Publications
The development of a facile gas sensor for the ppb-level detection of acetone is required for
realizing health diagnosis systems that utilize human breath. Controlling the crystal facet of a …

Ion mobility derived collision cross sections to support metabolomics applications

G Paglia, JP Williams, L Menikarachchi… - Analytical …, 2014 - ACS Publications
Metabolomics is a rapidly evolving analytical approach in life and health sciences. The
structural elucidation of the metabolites of interest remains a major analytical challenge in …

[HTML][HTML] Ion mobility spectrometry in food analysis: Principles, current applications and future trends

M Hernández-Mesa, D Ropartz, AM García-Campaña… - Molecules, 2019 - mdpi.com
In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical
separation technique, especially due to the commercialization of ion mobility mass …

Computational metabolomics: a framework for the million metabolome

K Uppal, DI Walker, K Liu, S Li, YM Go… - Chemical research in …, 2016 - ACS Publications
“Sola dosis facit venenum.” These words of Paracelsus,“the dose makes the poison”, can
lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance …