Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Cancer cells display a high rate of glycolysis in the presence of oxygen to promote
proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic …

Cancer cells constantly face a fluctuating nutrient supply and interference with adaptive
responses might be an effective therapeutic approach. It has been discovered that in the …

Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells,
little is known of the metabolic alterations within these cells that fuel invasion. We integrated …

Background Metabolic reprogramming is a well-known marker of cancer, and it represents
an early event during hepatocellular carcinoma (HCC) development. The recent approval of …

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can
simultaneously target GBM cells' ability to grow and migrate. Herein, we describe a …

Glioma is the most common primary malignant tumor in the central nervous system.
Disulfidptosis is a recently identified programmed cell death in tumor cells overexpressing …

De-regulated cellular energetics is an emerging hallmark of cancer with alterations to
glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and …

There is a need for enabling non-viral nanobiotechnology to allow safe and effective gene
therapy and cell therapy, which can be utilized to treat devastating diseases such as brain …