Traumatic brain injury (TBI) is the most common cause of death and disability in those aged
under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income …

There is a broad consensus that 21st century health care will require intensive use of
information technology to acquire and analyze data and then manage and disseminate …

Object Based on continuous monitoring of the pressure reactivity index (PRx), the authors
defined individualized intracranial pressure (ICP) thresholds by graphing the relationship …

Patients with acute brain injuries tend to be physiologically unstable and at risk of rapid and
potentially life-threatening decompensation due to shifts in intracranial compartment …

Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects
impaired energy metabolism. Raised LPR correlates with poor outcome and mortality …

Objective To assess the pathophysiologic changes in patients with spontaneous intracranial
hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms …

The pressure reactivity index (PRx) is a parameter for the assessment of cerebrovascular
autoregulation, but its calculation is affected by artifacts in the source biosignals …

Objective Loss of cerebral autoregulation (CA) plays a key role in secondary neurologic
injury. However, the regional distribution of CA impairment after acute cerebral injury …

OBJECTIVE The objective of this study was to examine how pulsatile and static intracranial
pressure (ICP) scores correlate with indices of intracranial pressure-volume reserve …

Current recommendations for the management of traumatic brain injury indicate ICP
monitoring in patients who remain comatose after resuscitation if the admission computed …