The role of the hippocampus in the consolidation of emotional memories during sleep

É Pronier, JF Morici, G Girardeau - Trends in Neurosciences, 2023 - cell.com
Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct
functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for …

Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala

R Nguyen, K Koukoutselos, T Forro, S Ciocchi - Science Advances, 2023 - science.org
Extinction memory retrieval is influenced by spatial contextual information that determines
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …

Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors

K Li, K Koukoutselos, M Sakaguchi… - Nature Communications, 2024 - nature.com
In emotion research, anxiety and fear have always been interconnected, sharing
overlapping brain structures and neural circuitry. Recent investigations, however, have …

Activity of ventral hippocampal parvalbumin interneurons during anxiety

E Volitaki, T Forro, K Li, T Nevian, S Ciocchi - Cell reports, 2024 - cell.com
Anxiety plays a key role in guiding behavior in response to potential threats. Anxiety is
mediated by the activation of pyramidal neurons in the ventral hippocampus (vH), whose …

Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI

P Tiwari, PA Davoudian, D Kapri, RM Vuruputuri… - Neuron, 2024 - cell.com
There has been a recent renewal of interest in the therapeutic potential of serotonergic
psychedelics. Here, we uncover the essential role of ventral hippocampus (vHpc) …

Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiation

EV Parkins, DH Brager, JK Rymer, JM Burwinkel… - Scientific Reports, 2023 - nature.com
MicroRNAs are an emerging class of synaptic regulators. These small noncoding RNAs post-
transcriptionally regulate gene expression, thereby altering neuronal pathways and shaping …

Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

L Sun, Z Zhao, J Guo, Y Qin, Q Yu, X Shi… - Neural regeneration …, 2024 - journals.lww.com
Transferring healthy and functional mitochondria to the lateral ventricles confers
neuroprotection in a rat model of ischemia-reperfusion injury. Autologous mitochondrial …

[HTML][HTML] Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in …

E Wei, A Gao, X Mu, S Qu, C Yang, F Li, S Li, X Liu… - Brain Research …, 2023 - Elsevier
Premenstrual dysphoric disorder (PMDD) is a periodic psychiatric disorder with high
prevalence in women of childbearing age, seriously affecting patients' work and life …

Hippocampal contextualization of social rewards in mice

JM Duarte, R Nguyen, M Kyprou, K Li… - Nature …, 2024 - nature.com
Acquiring and exploiting memories of rewarding experiences is critical for survival. The
spatial environment in which a rewarding stimulus is encountered regulates memory …

[HTML][HTML] Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat

LJ Leontiadis, P Felemegkas, G Trompoukis… - Developmental …, 2024 - karger.com
Introduction: Fragile X messenger ribonucleoprotein (FMRP) is a protein involved in many
neuronal processes in the nervous system including the modulation of synaptic …