The immunosuppressive molecule HLA-G and its clinical implications

Á González, V Rebmann, J LeMaoult… - Critical reviews in …, 2012 - Taylor & Francis
Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex
(MHC) class I molecule that, through interaction with its receptors, exerts important …

The role of classical and non-classical HLA class I antigens in human tumors

J Bukur, S Jasinski, B Seliger - Seminars in cancer biology, 2012 - Elsevier
In human tumors alterations in the surface expression and/or function of the major
histocompatibility complex (MHC) class I antigens are frequently found and equip neoplastic …

Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?

L Amiot, S Ferrone, H Grosse-Wilde… - Cellular and Molecular Life …, 2011 - Springer
Although the expression of the non-classical HLA class I molecule HLA-G was first reported
to be restricted to the fetal–maternal interface on the extravillous cytotrophoblasts, the …

Bee venom accelerates wound healing in diabetic mice by suppressing activating transcription factor‐3 (ATF‐3) and inducible nitric oxide synthase (iNOS)‐mediated …

G Badr, WN Hozzein, BM Badr… - Journal of cellular …, 2016 - Wiley Online Library
Multiple mechanisms contribute to impaired diabetic wound healing including impaired
neovascularization and deficient endothelial progenitor cell (EPC) recruitment. Bee venom …

Roles of HLA-G/KIR2DL4 in breast cancer immune microenvironment

G Zheng, L Jia, AG Yang - Frontiers in Immunology, 2022 - frontiersin.org
Human leukocyte antigen (HLA)-G is a nonclassical MHC Class I molecule, which was
initially reported as a mediator of immune tolerance when expressed in extravillous …

The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases

FC Dias, EC Castelli, CVA Collares, P Moreau… - Frontiers in …, 2015 - frontiersin.org
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic
properties, HLA-G expression is expected to be deleterious when present in tumor cells and …

Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients

S Jeong, S Park, BW Park, Y Park, OJ Kwon, HS Kim - PLoS One, 2014 - journals.plos.org
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune
escape mechanism in malignancies. The purpose of this study was to investigate HLA-G …

Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma

S Jasinski-Bergner, C Stoehr, J Bukur, C Massa… - …, 2015 - Taylor & Francis
In human tumors of distinct origin including renal cell carcinoma (RCC), the non-classical
human leukocyte antigen G (HLA-G) is frequently expressed, thereby inhibiting the cytotoxic …

[HTML][HTML] Thymoquinone rescues T lymphocytes from gamma irradiation-induced apoptosis and exhaustion by modulating pro-inflammatory cytokine levels and PD-1 …

MS Guida, AA El-Aal, Y Kafafy, SF Salama… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Recent studies have shown that thymoquinone (TQ) exerts protective
effects against ionizing radiation-induced cataracts in lens after total cranium irradiation of …

A meta-analysis on diagnostic accuracy of serum HLA-G level in breast cancer

S Sayad, SAY Ahmadi, M Moradi… - Expert Review of …, 2020 - Taylor & Francis
Background: According to the role of human leukocyte antigen (HLA)-G in tumor progression
and tumor escape from immune system as well as diagnostic role of biomarkers in breast …