Hepatitis B virus (HBV) infection, although preventable by vaccination, remains a global
health problem and a major cause of chronic liver disease. Although current treatment …

Photoredox chemistry has emerged as an efficient tool in catalyzing organic reactions as it
utilizes light as an energy source without any external initiator or reagent. The cyanide group …

Computer-aided synthesis planning (CASP) aims to assist chemists in performing
retrosynthetic analysis for which they utilize their experiments, intuition, and knowledge …

Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome
comprises partially double-stranded DNA, which is complexed with viral polymerase within …

Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize
the genetic materials of the virus itself, and they have become extremely favorable targets for …

Spiroannulation reactions are fundamental and invaluable for the synthesis of spirocyclic
compounds. Presented herein are novel cascade reactions of aryl azomethine imines with …

The identification of new targets to address unmet medical needs, better in a personalized
way, is an urgent necessity. The introduction of PARP1 inhibitors into therapy, almost ten …

Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of
deaths per year. Currently, there is no therapeutic that can completely cure already infected …

Abstract JNJ-64794964 (JNJ-4964/AL-034/TQ-A3334), an oral toll-like receptor 7 agonist, is
being investigated for the treatment of chronic hepatitis B (CHB), a condition with a high …

Despite the improving coverage of preventative vaccines, hepatitis B remains a severe
global public health problem, with more than 250 million patients living with hepatitis B virus …