The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a complex
spectrum of cellular and molecular characteristics including several dramatic changes in the …

Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
liver, which can cause liver disease and is linked with liver cancer. Viral innate immune …

Interferons initiate the host antiviral response by inducing a number of genes, most with no
defined antiviral function. Here we show that the interferon-induced protein viperin inhibits …

Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however,
their involvement in many critical aspects of the immune response including the interferon …

Viral infection of the cell is able to initiate a signaling cascade of events that ultimately
attempts to limit viral replication and prevent escalating infection through expression of host …

We have previously shown that Toll‐like receptor (TLR)‐activated murine nonparenchymal
liver cells [(NPC); Kupffer cells (KC), liver sinusoidal endothelial cells (LSEC)] can suppress …

Macrophages are key target cells for HIV-1. HIV-1BaL induced a subset of interferon-
stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in …

Lipid droplets are intracellular lipid-storage organelles that are thought to be derived from
the endoplasmic reticulum (ER). Several pathogens, notably hepatitis C virus, use lipid …