Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Charcot described amyotrophic lateral sclerosis (ALS) in 1874. Despite progress, this
creeping paralysis, known colloquially as Lou Gehrig's disease, is still not visibly affected by …

Mitochondrial control of cell death | Nature Medicine Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration, skeletal muscle
atrophy, paralysis, and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one …

The cause (s) of amyotrophic lateral sclerosis (ALS) is not fully understood in the vast
majority of cases and the mechanisms involved in motor neuron degeneration are multi …